IHC Diagnostics for Chronic Endometritis
Unlocking the Implantation Window
IHC (Immunohistochemistry) at Gynatal Clinic is the gold standard for diagnosing Chronic Endometritis, a silent inflammation of the uterine lining. By identifying specific markers like CD138 (plasma cells), our specialists can detect infections invisible to standard ultrasound. This diagnostic step is essential for patients with Recurrent Implantation Failure (RIF), as treating the inflammation significantly restores endometrial receptivity and IVF success rates.
Synergy: Chronic Endometritis and Endometriosis
It is critical to distinguish between endometriosis (tissue growing outside the uterus) and endometritida (inflammation inside the uterus). However, clinical data suggests that patients with endometriosis have a higher incidence of comorbid chronic endometritis, making endometrial evaluation an important step before IVF treatment.
- Pre-transfer Optimization: For patients at Gynatal diagnosed with endometriosis, we recommend ruling out chronic endometritis via IHC before the embryo transfer to maximize implantation probability.
- Diagnostic Hysteroscopy: The tissue sample for IHC is typically collected during a diagnostic hysteroscopy, a minimally invasive procedure performed at our clinic.
Integrated Diagnostics: IHC, imMAP, and ERA
Aligned with our "Scientific Gold Standard," we integrate IHC into a comprehensive Endometrial Health panel:
- IHC (CD138): Confirms the presence of inflammation at the cellular level.
- imMAP (Microbiome Mapping): Identifies bacterial imbalances (dysbiosis) that often trigger this inflammation.
- ERA Test: Determines if the lining is receptive at that moment or if the inflammation has shifted the implantation window