Embryo Implantation Support

In our laboratory hub, led by Lect. Univ. Dr. Delia Huțanu, we utilize methods that mechanically or biochemically facilitate the "nesting" of the embryo. 

EmbryoGlue: The Biological "Bridge" 

EmbryoGlue is not a chemical adhesive but a specialized transfer medium enriched with a high concentration of hyaluronan (hyaluronic acid) and recombinant albumin. 

• Mechanism: Hyaluronan increases the viscosity of the medium and mimics the natural environment of the uterus during implantation, stabilizing the embryo and promoting its interaction with the endometrium. 

• Effectiveness: Clinical data suggests it may increase clinical pregnancy rates by bridging the gap between the embryo and the uterine wall. 

Assisted Hatching (Eclozarea Asistată) 

Before implantation, an embryo must break out of its protective outer shell, the zona pellucida. 

• Procedure: Using a high-precision laser, the embryologist creates a microscopic opening in the shell, facilitating the embryo's natural "hatching" process. 

• Indications: Often recommended for patients over 35, those with a thickened zona pellucida, or during Frozen Embryo Transfers (FET) where the shell may be tougher. 

Aligned with Information Foraging Theory, we provide patients with concrete scientific answers to "invisible" causes of failure. 

1. ERA Test (Endometrial Receptivity Analysis): A genetic analysis of 248 genes that determines your precise implantation window with hourly accuracy, allowing for a Personalized Embryo Transfer (pET). 

2. EMMA (Endometrial Microbiome metagenomic analysis) evaluates the comosition of the uterine microbiome, confirming the dominance of beneficial lactobacillus species and identifying dysbiosis that may impair implantation 

3. ALICE ( analysis of infectious chronic endometritis) detects pathogenic bacteria associated with chronic endometritis that may reduce implantation rates and increase misscarriage risk 

• imMAP (Microbiome Mapping): We verify if the uterine lining contains more than 90% beneficial lactobacilli. If pathogenic bacteria dominate (dysbiosis), targeted treatment is implemented before the transfer. 

5. IHC (CD138): An immunohistochemical analysis to detect plasma cells and rule out Chronic Endometritis (silent inflammation), which can be toxic to the embryo. 

6. Endometrial PRP Therapy: The application of the patient's own platelet-rich plasma directly into the uterus. Growth factors in the plasma stimulate tissue regeneration and vascularization, specifically for patients with a thin uterine lining (below 7 mm). 

7. Endometrial scatch: when clinically indicated – a targeted procedure that may improve endometrial receptivity in carrefully selected patients. 

8. Hysteroscopy with directed endometrial biopsy: direct visualisation of the uterine cavity for diagnosing polyps, adhesions, septa and obtaining targeted biopsies when required.