Additional Investigations: Identifying the Hidden Causes of Infertility 

Advanced investigations at Gynatal Clinic (Timișoara) target immunological factors (KIR-HLA-C, ANA-ENA), thrombophilias, and endometrial health (ERA-EMMA-ALICE, IHC). Utilizing cutting-edge technologies, we provide personalized solutions for implantation failure and recurrent miscarriage, increasing success rates under the coordination of Lect. Univ. Dr. Delia Huțanu.

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Three Directions of High-Precision Diagnostics

Guided by our Information Foraging strategy, we categorize advanced tests to help patients navigate toward the solution for their specific diagnosis: 

1. Immune and hematological factors 

We focus on barriers that prevent proper embryo nutrition or cause the immune system to reject the pregnancy. 

  • Thrombophilia Profile: Identifying genetic mutations that increase the risk of blood clots in the placenta. Expert: Dr. Florica Ghilezan. 
  • KIR-HLA-C Genotyping:  Evaluates maternal KIR receptors and fetac HLA+C combinations in selected patients with recurrent implantation failure or recurrent pregnancy loss 
  • HT1/HT2 Testing: Analyzing the cytokine profile and the balance of helper T-lymphocytes. 
  • ANA-ENA Profile: Detecting autoantibodies that can create an inflammatory environment and impair fertility. 

2. Endometrial Health (The Uterine Environment) 

Tests designed to identify the optimal transfer window and eliminate "silent" inflammation. 

  • ERA-EMMA-ALICE (Complete Package): A triple-test for determining the implantation window (ERA), analyzing the microbiome (EMMA), and detecting pathogenic bacteria (ALICE). 
  • imMAP (Endometrial Microbiome): Advanced mapping of uterine flora to ensure the dominance of protective lactobacilli. 
  • IHC - Chronic Endometritis (CD138): Immunohistochemistry to diagnose chronic endometrial inflammation, which is often asymptomatic but prevents implantation. 

3. Advanced Male Factor (Genetic Integrity) 

A standard semen analysis may not be enough for complex cases involving embryo development arrest. 

  • Halosperm Test: Measuring sperm DNA fragmentation. High levels of DNA damage lead to arrested embryo development and lower pregnancy rates. 
  • Y- Chromosome microdeletion testing: recommended for men with severe oligozoospermia or azoospermia to identify genetic causes of impaired sperm production and guide treatment decisions 
  • Karyotype analysis: detects balanced chromosomal rearrangements that may contribute to recurrent pregnancy loss, repeated IVF failure, or severe male infertility 
  • CFTR gene testing: indicated in men with congenital bilateral absence of the vas deferens or obstructive azoosperia to identify cyctic fibrosis – related mutations 
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Why Gynatal is the "Scientific Gold Standard" in Advanced Diagnostics 

Multidisciplinary Integration: Results are co-evaluated by gynecologists, hematologists (Dr. Florica Ghilezan), and geneticistsDr. Simona Farcas) to create a 360-degree treatment plan. 
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Your Journey to Parenthood Starts in Timișoara

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Contact Gynatal Clinic, the leading assisted reproduction center in Western Romania and a proud member of the FutureLife network.

We provide comprehensive infertility treatments at our Timișoara headquarters. For appointments, call 0256 240 250.

  • Timișoara Headquarters (Full-Service Clinic)
    Address: Str. Protopop George Dragomir, nr. 1, Timișoara.
  • Phone (Call Center): 0256 240 250
  • Email: office@gynatal.ro