Implantation Failure

Experiencing a negative pregnancy test after an embryo transfer is a difficult milestone in the fertility journey. When this happens repeatedly—typically after two or more unsuccessful IVF cycles with high-quality embryos—it is clinically classified as Repeated Implantation Failure (RIF).

At Gynatal, we do not view implantation failure as a definitive end, but as a signal for deeper, more precise investigation. Data shows that even after repeated failures, 35–80% of couples can achieve a successful pregnancy when the protocol is scientifically adjusted.

Successful implantation requires a perfect "dialogue" between a healthy embryo and a receptive uterine environment. Our elite team, led by Medical Director Dr. Florin Dorneanu and Head of Lab Dr. Delia Huțanu, focuses on three primary factors:

The Embryo Factor: Chromosomal Health

The most common cause of failure is embryo aneuploidy—chromosomal abnormalities that are invisible under a standard microscope. Even an embryo that looks "perfect" (morphologically superior) may have genetic errors that prevent it from developing.

The Uterine Factor: The "Soil" for the Embryo

The uterus must provide a structurally sound and biochemically receptive environment.

• Displaced Implantation Window (ERA Test): For some patients, the "window of implantation" is open for a shorter time or at a different hour than the standard 5 days. Using the ERA (Endometrial Receptivity Analysis) test, we can determine the exact hour for transfer with molecular precision.
• Microbiome & Chronic Endometritis: Silent inflammation or a lack of beneficial Lactobacillus bacteria can reduce implantation success by over 50%. We offer comprehensive endometrial microbiome testing to optimize the "soil" before the next transfer.
• Endometrial Thickness (PRP Therapy): If the uterine lining remains thin (<7mm) despite medication, we utilize Endometrial PRP (Platelet-Rich Plasma) to stimulate natural tissue regeneration.

The Male Factor: DNA Integrity

High levels of sperm DNA fragmentation can lead to embryo developmental arrest even after successful fertilization. To counter this, we employ ZyMot selection chips or IMSI (magnification at 6000x) to select the most genetically stable sperm.