imMAP (Endometrial Microbiome Metagenomic Analysis)
Endometrial Microbiome Mapping at Gynatal Timișoara
imMAP (Endometrial Microbiome Metagenomic Analysis) at Gynatal Clinic is a high-precision genetic screening that evaluates the "uterine terrain" before embryo transfer. By analyzing the balance between beneficial lactobacilli and pathogenic bacteria, we identify "silent" causes of implantation failure. This diagnostic mapping is essential for patients with Recurrent Implantation Failure (RIF) to ensure the uterine environment is optimized for a successful pregnancy.
Understanding the Endometrial Microbiome
The uterine cavity was previously thought to be a sterile environment, but modern reproductive science at Gynatal confirms that a specific bacterial balance is necessary for successful implantation. Microbiome mapping identifies the microbiological composition of the endometrium, which directly affects the embryo's ability to attach.
The "Lactobacillus" Standard for Implantation
A healthy endometrium should ideally be composed of more than 90% lactobacilli. If this balance (eubiosis) is disrupted and pathogenic microorganisms or cocci predominate, a chronic inflammatory state is created. This "silent" dysbiosis can lead to the rejection of even a chromosomally healthy embryo.
Diagnostic Integration and the imMAP Process
Microbiome testing at Gynatal involves a metagenomic sequencing performed on a small sample of endometrial tissue obtained via biopsy. This procedure is technically very similar to the ERA test (Endometrial Receptivity Analysis).
Synergy with ERA and ni-PGT-A
As part of our "Scientific Gold Standard," we recommend combining microbiome mapping with other advanced diagnostics:
- ERA Test: Determines the exact implantation window—the precise hours when the uterine lining is most receptive.
- ni-PGT-A: Ensures we are transferring a chromosomally healthy embryo, while imMAP prepares the optimal "soil" for its reception.
Clinical Indications: Who Needs imMAP?
In line with our Flywheel Model, we eliminate uncertainty for patients who have experienced failed attempts by providing clear diagnostic roadmaps:
- Recurrent Implantation Failure (RIF): Unsuccessful transfers involving top-grade blastocysts.
- Recurrent pregnancy loss (RPL)
- Previous unsuccessful IVF cylces
- Unexplained Infertility: Cases where standard fertility check-ups have not revealed a cause for conception difficulties.
- Chronic Endometritis: Suspected hidden chronic inflammation of the uterine lining that is not visible via standard ultrasound
- Endometriosis
- Persistent vaginal dysbiosis or recurrent infections